PENK Polyclonal Antibody, 50ul Inoculating Loops/Needles It is proposed to regulate

It is proposed to regulate exchange of folded proteins for transport to the Golgi and exchange of misfolded glycoproteins for transport to the ubiquitin-proteasome pathway

induction:Down-regulated in cancer pancreatic cells undergoing differentiation and apoptosis

This gene encodes a member of the Rab subfamily of Ras-related small GTPases

The expression pattern of the mouse homolog implies a role in nervous system development

Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID)| in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins| whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia

PENK Polyclonal Antibody, 50ul Inoculating Loops/Needles It is proposed to regulatePENK(proenkephalin) encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met enkephalin and Leu enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu and delta opioid receptors to modulate the perception of pain. Other non opioid cleavage products may function in distinct biological activities.