c-Src(Phospho Tyr419) Polyclonal Antibody, 100ul[BT-AP06923] Bio-Reaction Tube IKBKE has also been identified

IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al

The protein is primarily expressed in brain

It binds the RI and RII subunits of PKA in testis

facial dysmorphism

Based on sequence and structural similarities

c-Src(Phospho Tyr419) Polyclonal Antibody, 100ul[BT-AP06923] Bio-Reaction Tube IKBKE has also been identifiedThis gene is highly similar to the v src gene of Rous sarcoma virus. This proto oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine protein kinase whose activity can be inhibited by phosphorylation by c SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for