Rat Growth/Differentiation Factor 11, GDF11 ELISA Kit, 96T DNA/RNA Isolation & Purification Dysregulated production of IL6 and

Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases

Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT)

calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins

BPTI/Kunitz inhibitor and E2 domains in the middle region

PubMed: 15805301)

Rat Growth/Differentiation Factor 11, GDF11 ELISA Kit, 96T DNA/RNA Isolation & Purification Dysregulated production of IL6 andSecreted signal that acts globally to specify positional identity along the anterior posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Signals through activin receptors type 2, ACVR2A and ACVR2B, and activin receptors type 1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3.