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CBX4 Rabbit Polyclonal Antibody, 50ul Nucleic Acid Extraction Expansion of a GGGGCC repeat

CBX4 Rabbit Polyclonal Antibody, 50ul Nucleic Acid Extraction Expansion of a GGGGCC repeat

Name: CBX4 Rabbit Polyclonal Antibody, 50ul Nucleic Acid Extraction Expansion of a GGGGCC repeat
Brand: trulybuild.in
SKU: 22067476471
Price: 185.00 USD
Availability: InStock
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SKU: 22067476471

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CBX4 Rabbit Polyclonal Antibody, 50ul Nucleic Acid Extraction Expansion of a GGGGCC repeat

Store: trulybuild.in · Domain: trulybuild.in

Description

Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778

Members of family C of the G protein-coupled receptor (GPCR) superfamily

In mammalian cells

The CARD domains of both proteins have been shown to specifically interact with BCL10| a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation

Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways

CBX4 Rabbit Polyclonal Antibody, 50ul Nucleic Acid Extraction Expansion of a GGGGCC repeat

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