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RUBIC Rabbit Polyclonal Antibody, 20ul Immunology The encoded preproprotein is proteolytically

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RUBIC Rabbit Polyclonal Antibody, 20ul Immunology The encoded preproprotein is proteolyticallyThe protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains an N terminal RUN domain and a C terminal DUF4206 domain. The RUN domain is involved in Ras like GTPase signaling and the DUF4206 domain contains a diacylglycerol (DAG) binding like motif. Mutation in this gene results in deletion of the DAG binding like motif and causes a

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Description

The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor

and are involved in a variety of biological processes including embryonic development cell growth

The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form

It is suggested that the NRGN is a direct target for thyroid hormone in human brain| and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects

• Braking time 2 steps adjustable only for A6-50P rotor

RUBIC Rabbit Polyclonal Antibody, 20ul Immunology The encoded preproprotein is proteolyticallyThe protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains an N terminal RUN domain and a C terminal DUF4206 domain. The RUN domain is involved in Ras like GTPase signaling and the DUF4206 domain contains a diacylglycerol (DAG) binding like motif. Mutation in this gene results in deletion of the DAG binding like motif and causes a

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