MDM2(Phospho Ser186/S188) Polyclonal Antibody, 100ul Mammalian Expression Several alternatively spliced transcript variants

Several alternatively spliced transcript variants have been described for this gene

The larger transcript is approximately 13

it has been demonstrated that the protein actually has protein disulfide isomerase activity

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This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors

MDM2(Phospho Ser186/S188) Polyclonal Antibody, 100ul Mammalian Expression Several alternatively spliced transcript variantsThis gene encodes a nuclear localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript