LPCT4 Polyclonal Antibody, 50ul Cell Biology Diphthamide is a post-translationally modified

Diphthamide is a post-translationally modified histidine residue present in elongation factor 2| and is the target of diphtheria toxin

It also contains a destruction box (D box) that is required for its degradation by the APC

It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs

The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF)

Mutations in this gene are associated with slow-channel congenital myasthenic syndrome

LPCT4 Polyclonal Antibody, 50ul Cell Biology Diphthamide is a post-translationally modifiedMembers of the 1 acylglycerol 3 phosphate O acyltransferase (EC 2. 3. 1. 51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005