Rb(Phospho-Ser807/811) Rabbit Polyclonal Antibody, 20ul Serological Pipets A pseudogene corresponding to this

A pseudogene corresponding to this gene is found on chromosome 20

Multiple capacities and well configurations are available for different experimental needs

Originally localized to both chromosomes 2 and 7

that have been divided into 3 groups on the basis of sequence homology

Defects in CLCN7 are the cause of osteopetrosis autosomal recessive type 4 (OPTB4)

Rb(Phospho-Ser807/811) Rabbit Polyclonal Antibody, 20ul Serological Pipets A pseudogene corresponding to thisThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB) bladder cancer and osteogenic sarcoma.