SFRP1 Polyclonal Antibody, 20ul Protein Expression Mutations in this gene have

Mutations in this gene have been associated with geleophysic dysplasia

also known as epilepsy

It is highly expressed in adrenal gland

Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity)

Mediates apoptosis and actin stress fiber dissolution

SFRP1 Polyclonal Antibody, 20ul Protein Expression Mutations in this gene haveThis gene encodes a member of the SFRP family that contains a cysteine rich domain homologous to the putative Wnt binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina.